Comparative binder efficiency modeling of dry granulation binders using roller compaction.
Drug Dev Ind Pharm. 2017 Apr;43(4):574-583. doi: 10.1080/03639045.2016.1272118. Epub 2017 Jan 5. Gupte A1, DeHart M1, Stagner WC2, Haware RV2. Author information 1 a Mayne Pharma Inc , Greenville , NC , USA. 2 b Campbell University College of Pharmacy & Health Sciences , Buies Creek , NC , USA. Abstract Roller compaction parameters’ impact on granules and tableting […]
Crospovidone and Microcrystalline Cellulose: A Novel Description of Pharmaceutical Fillers in the Gastrointestinal Tract.
Am J Surg Pathol. 2017 Apr;41(4):564-569. doi: 10.1097/PAS.0000000000000790. Shaddy SM1, Arnold MA, Shilo K, Frankel WL, Harzman AE, Stanich PP, Singhi AD, Yearsley MM, Arnold CA. Author information 1 Departments of *Pathology ‡Surgery §Division of Gastroenterology, Hepatology & Nutrition, The Ohio State University Wexner Medical Center †Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OH ∥Department of Pathology, University of Pittsburgh Medical […]
Pharmaceutical development of an amorphous solid dispersion formulation of elacridar hydrochloride for proof-of-concept clinical studies.
Drug Dev Ind Pharm. 2017 Apr;43(4):584-594. doi: 10.1080/03639045.2016.1274901. Epub 2017 Jan 8. Sawicki E1, Schellens JH2,3, Beijnen JH1,2,3, Nuijen B1. Author information 1 a Department of Pharmacy and Pharmacology , Antoni van Leeuwenhoek Hospital/MC Slotervaart , Amsterdam , The Netherlands. 2 b Department of Clinical Pharmacology , the Netherlands Cancer Institute , Amsterdam , the Netherlands. 3 c Faculty […]
Difference in the Dissolution Behaviors of Tablets Containing Polyvinylpolypyrrolidone (PVPP) Depending on Pharmaceutical Formulation After Storage Under High Temperature and Humid Conditions.
J Pharm Pharm Sci. 2016 Oct – Dec;19(4):511-519. doi: 10.18433/J3HW3Q. Takekuma Y1, Ishizaka H, Sumi M, Sato Y, Sugawara M. Author information 1 Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. Abstract PURPOSE: Storage under high temperature and humid conditions has been reported to decrease the dissolution rate for some kinds of tablets containing polyvinylpolypyrrolidone (PVPP) as a disintegrant. The aim of […]
A minitablet formulation made from electrospun nanofibers.
Eur J Pharm Biopharm. 2017 May;114:213-220. doi: 10.1016/j.ejpb.2017.01.022. Epub 2017 Feb 4. Poller B1, Strachan C2, Broadbent R3, Walker GF4. Author information 1 School of Pharmacy, University of Otago, Dunedin, New Zealand. 2 Division of Pharmaceutical Technology, University of Helsinki, Helsinki, Finland. 3 Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. 4 School of Pharmacy, University of […]
Oral bioavailability enhancement of flubendazole by developing nanofibrous solid dosage forms.
Drug Dev Ind Pharm. 2017 Jul;43(7):1126-1133. doi: 10.1080/03639045.2017.1298121. Epub 2017 Mar 8. Vigh T1, Démuth B1, Balogh A1, Galata DL1, Van Assche I2, Mackie C2, Vialpando M2, Van Hove B2, Psathas P2, Borbás E1, Pataki H1, Boeykens P2, Marosi G1, Verreck G2, Nagy ZK1. Author information 1 a Department of Organic Chemistry and Technology , Budapest University of Technology and Economics , Budapest , Hungary. 2 b Drug Product Development, […]
A pharmaceutical study on lornoxicam fast disintegrating tablets: formulation and in vitro and in vivo evaluation.
Drug Deliv Transl Res. 2017 Jun;7(3):450-459. doi: 10.1007/s13346-017-0367-6. Moutasim MY1, ElMeshad AN2, El-Nabarawi MA2. Author information 1 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr el-Aini St, Cairo, 11562, Egypt. Mohamed-aboyousif@hotmail.com. 2 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr el-Aini St, Cairo, 11562, Egypt. Abstract Lornoxicam is an anti-inflammatory […]
[Application of synthetic and semisynthetic polymers (Kollidon K30 and hydroxypropylmethylcellulose) as carriers of ketoprofen in solid oral prolonged-release dosage forms].
Polim Med. 2016 Jul-Dec;46(2):145-153. doi: 10.17219/pim/69296. [Article in Polish] Linka W1, Kot M1, Kołodziejczyk M1. Author information 1 Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska. Abstract BACKGROUND: One of the most important challenges of the modern technology of solid oral dosage forms is to increase the effectiveness of the drug, reduce side effects and improve […]
New gentle-wing high-shear granulator: impact of processing variables on granules and tabletscharacteristics of high-drug loading formulation using design of experiment approach.
Drug Dev Ind Pharm. 2017 Oct;43(10):1584-1600. doi: 10.1080/03639045.2017.1326930. Epub 2017 May 19. Fayed MH1, Abdel-Rahman SI2, Alanazi FK3, Ahmed MO2, Tawfeek HM2, Al-Shdefat RI1. Author information Abstract The aim of this work was to study the application of design of experiment (DoE) approach in defining design space for granulation and tableting processes using a novel gentle-wing high-shear granulator. According to quality-by-design […]
Evaluation of disintegrants functionality for orodispersible mini tablets.
Drug Dev Ind Pharm. 2017 Nov;43(11):1770-1779. doi: 10.1080/03639045.2017.1339081. Epub 2017 Jun 21. Soulairol I1,2, Chaheen M1,3, Tarlier N1, Aubert A1, Bataille B1, Sharkawi T1. Author information 1 a UMR 5253, Equipe MACS, ICGM, University of Montpellier , Montpellier , France. 2 b Department of Pharmacy , Nîmes University Hospital , Nimes , France. 3 c Ecole Doctorale des Sciences et Technologie […]