[title type=”extra-large” color=”#000000″]Mendonyl™ Crospovidone (PVPP)[/title]
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[title type=”subtitle-h3″ color=”#999″ animation=”top-to-bottom”]Extraordinary disintegration for tablets: Easy, Fast, Foolproof.[/title]
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[icon_feature icon=”hb-moon-eye-2″ icon_position=”center” border=”yes” title=”Applications”]Numerous studies (visit our BLOG for more) have proven time again, PVPP’s incredible array of applications, including disintegrate, binder, stabilizer in beverages, and more.[/icon_feature]
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[icon_feature icon=”hb-moon-brain” icon_position=”center” border=”yes” title=”Flexibility”]Prevent failure by taking advantage of PVPP’s ability to adapt to active compounds in tablets and many other dosage forms, while maintaining stability and quality through all the rigorous production processes, including Spray-drying and roller compaction. With a wide usage range (as low as 1%), achieving solid powders and tablets that nearly instantly break apart, is at the core of Crospovidone.[/icon_feature]
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[icon_feature icon=”hb-moon-palette” icon_position=”center” border=”yes” title=”Tough”]Recognized, peer-reviewed backed science, means the production of tablets that readily compress, and rapidly dissolve in the stomach.
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WHAT IS CROSPOVIDONE?
Crospovidone, a cross-linked polyvinylpyrrolidone (PVPP), is an inert and insoluble polymer commonly found in pharmaceutical and nutritional tablets as a super-disintegrant. Crospovidone’s powerful water absorption abilities, creates a near-immediate swelling of a tablet at contact with water; thus, releasing the active drug in an accelerated and precise manner. LEARN MORE AT OUR BLOG.
MENDONYL™ XL, XL-10.
Almost white free-flowing powder.
They have a slight characteristic odor, and are practically tasteless.
| TEST | Mendonyl™ XL | Mendonyl™ XL-10 |
| Identification, A B C | Pass | Pass |
| Identification D | Type A | Type B |
| Solubility (Insoluble in ) | practically insoluble in water | |
| PH ( in 1% suspension ) | 5.0 – 8.0 | 5.0 – 8.0 |
| Loss on drying | ≦5.0% | ≦5.0% |
| Water | ≦5.0% | ≦5.0% |
| Water-soluble matter | ≦1.0% | ≦1.0% |
| Acid-Alcohol soluble matter | ≦1.0% | ≦1.0% |
| Peroxides ( as H2O2 ) | ≦400ppm | ≦400ppm |
| Free N-vinylpyrrolidone | ≦10ppm | ≦10ppm |
| Residue on ignition | ≦0.1% | ≦0.1% |
| Heavy metals | ≦10ppm | ≦10ppm |
| Assay, as Nitrogen content | 11.0 – 12.8 | 11.0 – 12.8 |
MENDONYL™ K25, K30, K90
| MICROBIOLOGICAL STATUS | MAX 100 Aerobic Plate Count CFU/g | |||
| MAX 100 Mold and Yeast CFU/g | ||||
| No Escherichia /g | ||||
| No Pseudomonas aeruginosa /g | ||||
| No Salmonella /10g | ||||
| No Staphylococcus aureus /g | ||||
Freely soluble in water and many organic compounds.
Griseofulvin Tablets
| Ingredients | mg/tab |
| Griseofulvin | 500 |
| Povidone (VA 64) | 100 |
| Dimethylformamide | 7500 |
| Crospovidone | 75 |
| Lactose monohydrate | 75 |
| Magnesium stearate | 5 |
| Colloidal silicon dioxide | 5 |
Sulfadimidine Tablets
| Ingredients | mg/tab |
| Sulfadimidine | 500 |
| Lactose monohydrate | 100 |
| Povidone (K30) | 15 |
| Purified water | 200 |
| Crospovidone | 25 |
| Talc | 2.4 |
| Colloidal silicon dioxide | 0.3 |
| Calcium arachinate | 0.3 |
Captopril Tablets
| Ingredients | mg/tab |
| Captopril | 25 |
| Ludipress | 91 |
| Crospovidone | 2 |
| Magnesium stearate | 2 |
Mefenamic Acid Tablets
| Ingredients | mg/tab |
| Mefenamic acid | 250 |
| Cornstarch | 30 |
| Povidone (90F) | 50 |
| Isopropyl alcohol | QS |
| Crospovidone | 12 |
| Microcrystalline cellulose 101 | 85 |
| Magnesium stearate | 5 |
Probenecid Tablets
| Ingredients | mg/tab |
| Probenecid | 500 |
| Cornstarch | 130 |
| Povidone (K30) | 10 |
| Alcohol | 70.00 mL |
| Crospovidone | 25 |
| Colloidal silicon dioxide | 3 |
| Magnesium stearate | 3 |
Raloxifene Hydrochloride Tablets
| Ingredients | mg/tab |
| Raloxifene HCl | 60 |
| Lactose anhydrous | 156 |
| Povidone | 7.2 |
| Polysorbate 80 | 7.2 |
| Crospovidone | 7.2 |
| Magnesium stearate | 2.4 |
Fucidine Tablets (125 mg)
| Ingredients | mg/tab |
| Fucidine | 125 |
| Dicalcium phosphate (Di-Tab) | 63 |
| Povidone (90F) | 2.5 |
| Isopropyl alcohol | 30 mL |
| Crospovidone | 6.2 |
| Colloidal silicon dioxide | 1.3 |
| Magnesium stearate | 3 |
Vitamin B-Complex, Vitamin C, and Calcium Effervescent Tablets
| Ingredients | mg/tab |
| Thiamine mononitrate | 7 |
| Riboflavin | 5 |
| Nicotinamide | 25 |
| Pyridoxine hydrochloride | 20 |
| Calcium D-pantothenate | 12 |
| Calcium carbonate | 75 |
| Calcium glycerophosphate | 164 |
| Sodium bicarbonate | 400 |
| Tartaric acid (powder) | 300 |
| Sucrose | 400 |
| Sucrose | 350 |
| Povidone (K30) | 50 |
| Povidone (K30) | 10 |
| Isopropanol | QS |
| Ascorbic acid (powder) | 550 |
| Riboflavin | 2 |
| Cyanocobalamin (gelatin coated, 0.1%) | 5 |
| PEG-6000 (powder) | 40 |
| Crospovidone | 50 |
(source: handbook of Pharmaceutical Manufacturing Formulations, Compressed Solid Products. Author: Sarfaraz K. Niazi)
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