Formulation and Dissolution enhancement of Meloxicam tablets using Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer and Povidone in combination.
Pak J Pharm Sci. 2017 Mar;30(2):407-414. Noor R1, Hasan SMF1, Hassan F1, Rehman A2. Author information 1 Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan. 2 Merck Pharmaceutical Industry (Pvt.) Ltd., S.I.T.E., Karachi, Pakistan. Abstract Meloxicam is a poor water soluble drug mostly prescribed in various rheumatic diseases. The present research study was […]
Influence of polyvinylpyrrolidone, microcrystalline cellulose and colloidal silicon dioxide on technological characteristics of a high-dose Petiveria alliacea tablet.
Drug Dev Ind Pharm. 2017 Dec;43(12):2011-2015. doi: 10.1080/03639045.2017.1359621. Epub 2017 Aug 3. García-Pérez ME1,2, Lemus-Rodríguez Z1, Hung-Arbelo M1, Vistel-Vigo M1. Author information 1 a Laboratorio Farmacéutico Oriente , Santiago de Cuba , Cuba. 2 b Facultad de Químico-Farmacobiología , Universidad Michoacana de San Nicolás de Hidalgo , Morelia , Michoacán , Mexico. Abstract PURPOSE: Petiveria alliacea L. (Phytolaccaceae) is […]
Study of controlled-release floating tablets of dipyridamole using the dry-coated method.
Drug Dev Ind Pharm. 2018 Jan;44(1):116-124. doi: 10.1080/03639045.2017.1386198. Epub 2017 Oct 17. Chen K1, Wen H1, Yang F1, Yu Y1, Gai X1, Wang H1, Li P1, Pan W1, Yang X1. Author information 1 a Department of Pharmaceutics , School of Pharmaceutical Sciences, Shenyang Pharmaceutical University , Shenyang , China. Abstract Dipyridamole (DIP), having a short biological half-life, has a narrow absorption window and is […]
Formulation strategy towards minimizing viscosity mediated negative food effect on disintegration and dissolution of immediate release tablets.
Formulation strategy towards minimizing viscosity mediated negative food effect on disintegration and dissolution of immediate release tablets. Zaheer K1, Langguth P1. Author information 1 a Institute of Pharmacy and Biochemistry , Johannes Gutenberg-Universität , Mainz , Germany. Drug Dev Ind Pharm. 2018 Mar;44(3):444-451. doi: 10.1080/03639045.2017.1397685. Epub 2017 Nov 10. Abstract Food induced viscosity can delay disintegration and subsequent […]
Design and Evaluation of Bilayer Pump Tablet of Flurbiprofen Solid Dispersion for Zero-Order Controlled Delivery.
Design and Evaluation of Bilayer Pump Tablet of Flurbiprofen Solid Dispersion for Zero-Order Controlled Delivery. Cheng L1, Li T1, Dong L1, Wang X1, Huo Q1, Wang H1, Jiang Z1, Shan X1, Pan W1, Yang X2. Author information J Pharm Sci. 2017 Dec 29. pii: S0022-3549(17)30908-5. doi: 10.1016/j.xphs.2017.12.026. [Epub ahead of print] 1 Department of Pharmaceutics, School of Pharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, […]
The Impact of Amorphisation and Spheronization Techniques on the Improved in Vitro & in Vivo Performance of Glimepiride Tablets.
Makar RR1, Latif R2, Hosni EA3, El Gazayerly ON2. Author information Adv Pharm Bull. 2017 Dec;7(4):557-567. doi: 10.15171/apb.2017.067. Epub 2017 Dec 31. Abstract Purpose: Triple solid dispersion adsorbates (TSDads) and spherical agglomerates (SA) present new techniques that extensively enhance dissolution of poorly soluble drugs. The aim of the present study is to hasten the onset of hypoglycemic effect of glimepiride […]
Statistical moments in modelling of swelling, erosion and drug release of hydrophilic matrix-tablets.
Abstract Statistical moments were evaluated as suitable parameters for describing swelling and erosion processes (along with drug release) in hydrophilic controlled release matrix tablets. The effect of four independent formulation variables, corresponding to the quantity of four polymeric matrix excipients (namely polyethylene glycol, povidone, and two grades of hydroxyl-propylmethyl cellulose) on statistical moments describing swelling (mean swelling […]
Development and analytical characterization of a new antiparasitic fenbendazole compound tablet and pharmacokinetic investigations after its oral administration to dogs.
Abstract The objective of this study was to prepare a new compound fenbendazole tablet containing 29.7 % fenbendazole, 1.50 % praziquantel and 0.059 % ivermectin for oral administration. The tablets were successfully prepared using mannitol as filler agent, polyvinyl polypyrrolidone as disintegrant, 5 % povidone (PVAK30) as a binder agent and magnesium stearate as lubricant. The appearance, hardness, fragility, time limit […]
IDENTIFICATION OF PHARMACEUTICAL EXCIPIENT BEHAVIOR OF CHICKPEA (CICER ARIETINUM) STARCH IN GLICLAZIDE IMMEDIATE RELEASE TABLETS.
Abstract In the past few years, there are number of researchers carrying out their research on the excipients derived from polysaccharides and some of these researches show that natural excipients are comparable and can serve as an alternative to the synthetic excipients. Hence, the objectives of this research are to characterize the naturally sourced chickpea […]
A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets.
Abstract Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique and utilizing three lipid carriers: […]