Crospovidone and Microcrystalline Cellulose: A Novel Description of Pharmaceutical Fillers in the Gastrointestinal Tract.
Am J Surg Pathol. 2017 Apr;41(4):564-569. doi: 10.1097/PAS.0000000000000790. Shaddy SM1, Arnold MA, Shilo K, Frankel WL, Harzman AE, Stanich PP, Singhi AD, Yearsley MM, Arnold CA. Author information 1 Departments of *Pathology ‡Surgery §Division of Gastroenterology, Hepatology & Nutrition, The Ohio State University Wexner Medical Center †Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OH ∥Department of Pathology, University of Pittsburgh Medical […]
Difference in the Dissolution Behaviors of Tablets Containing Polyvinylpolypyrrolidone (PVPP) Depending on Pharmaceutical Formulation After Storage Under High Temperature and Humid Conditions.
J Pharm Pharm Sci. 2016 Oct – Dec;19(4):511-519. doi: 10.18433/J3HW3Q. Takekuma Y1, Ishizaka H, Sumi M, Sato Y, Sugawara M. Author information 1 Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. Abstract PURPOSE: Storage under high temperature and humid conditions has been reported to decrease the dissolution rate for some kinds of tablets containing polyvinylpolypyrrolidone (PVPP) as a disintegrant. The aim of […]
A pharmaceutical study on lornoxicam fast disintegrating tablets: formulation and in vitro and in vivo evaluation.
Drug Deliv Transl Res. 2017 Jun;7(3):450-459. doi: 10.1007/s13346-017-0367-6. Moutasim MY1, ElMeshad AN2, El-Nabarawi MA2. Author information 1 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr el-Aini St, Cairo, 11562, Egypt. Mohamed-aboyousif@hotmail.com. 2 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr el-Aini St, Cairo, 11562, Egypt. Abstract Lornoxicam is an anti-inflammatory […]
Evaluation of disintegrants functionality for orodispersible mini tablets.
Drug Dev Ind Pharm. 2017 Nov;43(11):1770-1779. doi: 10.1080/03639045.2017.1339081. Epub 2017 Jun 21. Soulairol I1,2, Chaheen M1,3, Tarlier N1, Aubert A1, Bataille B1, Sharkawi T1. Author information 1 a UMR 5253, Equipe MACS, ICGM, University of Montpellier , Montpellier , France. 2 b Department of Pharmacy , Nîmes University Hospital , Nimes , France. 3 c Ecole Doctorale des Sciences et Technologie […]
Formulation strategy towards minimizing viscosity mediated negative food effect on disintegration and dissolution of immediate release tablets.
Formulation strategy towards minimizing viscosity mediated negative food effect on disintegration and dissolution of immediate release tablets. Zaheer K1, Langguth P1. Author information 1 a Institute of Pharmacy and Biochemistry , Johannes Gutenberg-Universität , Mainz , Germany. Drug Dev Ind Pharm. 2018 Mar;44(3):444-451. doi: 10.1080/03639045.2017.1397685. Epub 2017 Nov 10. Abstract Food induced viscosity can delay disintegration and subsequent […]
The Impact of Amorphisation and Spheronization Techniques on the Improved in Vitro & in Vivo Performance of Glimepiride Tablets.
Makar RR1, Latif R2, Hosni EA3, El Gazayerly ON2. Author information Adv Pharm Bull. 2017 Dec;7(4):557-567. doi: 10.15171/apb.2017.067. Epub 2017 Dec 31. Abstract Purpose: Triple solid dispersion adsorbates (TSDads) and spherical agglomerates (SA) present new techniques that extensively enhance dissolution of poorly soluble drugs. The aim of the present study is to hasten the onset of hypoglycemic effect of glimepiride […]
Development and analytical characterization of a new antiparasitic fenbendazole compound tablet and pharmacokinetic investigations after its oral administration to dogs.
Abstract The objective of this study was to prepare a new compound fenbendazole tablet containing 29.7 % fenbendazole, 1.50 % praziquantel and 0.059 % ivermectin for oral administration. The tablets were successfully prepared using mannitol as filler agent, polyvinyl polypyrrolidone as disintegrant, 5 % povidone (PVAK30) as a binder agent and magnesium stearate as lubricant. The appearance, hardness, fragility, time limit […]
Novel approach of aceclofenac fast dissolving tablet.
Abstract Fast disintegrating tablets (FDTs) have received ever increasing demand during the last decade, and the field has become a hastily growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. Aceclofenac, an […]
Crospovidone and Microcrystalline Cellulose: A Novel Description of Pharmaceutical Fillers in the Gastrointestinal Tract.
Abstract Crospovidone and microcrystalline cellulose (MCC) are pharmaceutical fillers well known in the pulmonary pathology literature. Fillers are inactive substances incorporated into medications to facilitate drug delivery. By examining 545 consecutive gastrointestinal surgical specimens from 302 patients between September 11, 2015 and October 23, 2015, we identified the fillers in 29 specimens from 26 patients. The control […]