Comparative binder efficiency modeling of dry granulation binders using roller compaction.
Drug Dev Ind Pharm. 2017 Apr;43(4):574-583. doi: 10.1080/03639045.2016.1272118. Epub 2017 Jan 5. Gupte A1, DeHart M1, Stagner WC2, Haware RV2. Author information 1 a Mayne Pharma Inc , Greenville , NC , USA. 2 b Campbell University College of Pharmacy & Health Sciences , Buies Creek , NC , USA. Abstract Roller compaction parameters’ impact on granules and tableting […]
Pharmaceutical development of an amorphous solid dispersion formulation of elacridar hydrochloride for proof-of-concept clinical studies.
Drug Dev Ind Pharm. 2017 Apr;43(4):584-594. doi: 10.1080/03639045.2016.1274901. Epub 2017 Jan 8. Sawicki E1, Schellens JH2,3, Beijnen JH1,2,3, Nuijen B1. Author information 1 a Department of Pharmacy and Pharmacology , Antoni van Leeuwenhoek Hospital/MC Slotervaart , Amsterdam , The Netherlands. 2 b Department of Clinical Pharmacology , the Netherlands Cancer Institute , Amsterdam , the Netherlands. 3 c Faculty […]
A minitablet formulation made from electrospun nanofibers.
Eur J Pharm Biopharm. 2017 May;114:213-220. doi: 10.1016/j.ejpb.2017.01.022. Epub 2017 Feb 4. Poller B1, Strachan C2, Broadbent R3, Walker GF4. Author information 1 School of Pharmacy, University of Otago, Dunedin, New Zealand. 2 Division of Pharmaceutical Technology, University of Helsinki, Helsinki, Finland. 3 Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. 4 School of Pharmacy, University of […]
Oral bioavailability enhancement of flubendazole by developing nanofibrous solid dosage forms.
Drug Dev Ind Pharm. 2017 Jul;43(7):1126-1133. doi: 10.1080/03639045.2017.1298121. Epub 2017 Mar 8. Vigh T1, Démuth B1, Balogh A1, Galata DL1, Van Assche I2, Mackie C2, Vialpando M2, Van Hove B2, Psathas P2, Borbás E1, Pataki H1, Boeykens P2, Marosi G1, Verreck G2, Nagy ZK1. Author information 1 a Department of Organic Chemistry and Technology , Budapest University of Technology and Economics , Budapest , Hungary. 2 b Drug Product Development, […]
[Application of synthetic and semisynthetic polymers (Kollidon K30 and hydroxypropylmethylcellulose) as carriers of ketoprofen in solid oral prolonged-release dosage forms].
Polim Med. 2016 Jul-Dec;46(2):145-153. doi: 10.17219/pim/69296. [Article in Polish] Linka W1, Kot M1, Kołodziejczyk M1. Author information 1 Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska. Abstract BACKGROUND: One of the most important challenges of the modern technology of solid oral dosage forms is to increase the effectiveness of the drug, reduce side effects and improve […]
New gentle-wing high-shear granulator: impact of processing variables on granules and tabletscharacteristics of high-drug loading formulation using design of experiment approach.
Drug Dev Ind Pharm. 2017 Oct;43(10):1584-1600. doi: 10.1080/03639045.2017.1326930. Epub 2017 May 19. Fayed MH1, Abdel-Rahman SI2, Alanazi FK3, Ahmed MO2, Tawfeek HM2, Al-Shdefat RI1. Author information Abstract The aim of this work was to study the application of design of experiment (DoE) approach in defining design space for granulation and tableting processes using a novel gentle-wing high-shear granulator. According to quality-by-design […]
Formulation and Dissolution enhancement of Meloxicam tablets using Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer and Povidone in combination.
Pak J Pharm Sci. 2017 Mar;30(2):407-414. Noor R1, Hasan SMF1, Hassan F1, Rehman A2. Author information 1 Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan. 2 Merck Pharmaceutical Industry (Pvt.) Ltd., S.I.T.E., Karachi, Pakistan. Abstract Meloxicam is a poor water soluble drug mostly prescribed in various rheumatic diseases. The present research study was […]
Influence of polyvinylpyrrolidone, microcrystalline cellulose and colloidal silicon dioxide on technological characteristics of a high-dose Petiveria alliacea tablet.
Drug Dev Ind Pharm. 2017 Dec;43(12):2011-2015. doi: 10.1080/03639045.2017.1359621. Epub 2017 Aug 3. García-Pérez ME1,2, Lemus-Rodríguez Z1, Hung-Arbelo M1, Vistel-Vigo M1. Author information 1 a Laboratorio Farmacéutico Oriente , Santiago de Cuba , Cuba. 2 b Facultad de Químico-Farmacobiología , Universidad Michoacana de San Nicolás de Hidalgo , Morelia , Michoacán , Mexico. Abstract PURPOSE: Petiveria alliacea L. (Phytolaccaceae) is […]
Study of controlled-release floating tablets of dipyridamole using the dry-coated method.
Drug Dev Ind Pharm. 2018 Jan;44(1):116-124. doi: 10.1080/03639045.2017.1386198. Epub 2017 Oct 17. Chen K1, Wen H1, Yang F1, Yu Y1, Gai X1, Wang H1, Li P1, Pan W1, Yang X1. Author information 1 a Department of Pharmaceutics , School of Pharmaceutical Sciences, Shenyang Pharmaceutical University , Shenyang , China. Abstract Dipyridamole (DIP), having a short biological half-life, has a narrow absorption window and is […]
Statistical moments in modelling of swelling, erosion and drug release of hydrophilic matrix-tablets.
Abstract Statistical moments were evaluated as suitable parameters for describing swelling and erosion processes (along with drug release) in hydrophilic controlled release matrix tablets. The effect of four independent formulation variables, corresponding to the quantity of four polymeric matrix excipients (namely polyethylene glycol, povidone, and two grades of hydroxyl-propylmethyl cellulose) on statistical moments describing swelling (mean swelling […]