Design and evaluation of microwave-treated orally disintegrating tablets containing polymeric disintegrant and mannitol.
Abstract Microwave (MW) treatment was used to develop a formulation process for the preparation of wet molded orally disintegrating tablets (ODTs) consisting of mannitol and polymeric disintegrant with improved hardness and disintegration properties. The wet molded tablets were prepared in accordance with the conventional methods and subsequently heated by MW irradiation to induce the swelling […]
Microparticle surface layering through dry coating: impact of moisture content and process parameters on the properties of orally disintegrating tablets.
Abstract OBJECTIVES: The aim of this study was to investigate the influence of process parameters during dry coating on particle and dosageform properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs). METHODS: The moisture content of MCC was optimised using the spray water method and analysed using thermogravimetric […]