Evaluation of ethylcellulose and its pseudolatex (Surelease) in preparation of matrix pellets of theophylline using extrusion-spheronization.
Abstract OBJECTIVES: This study evaluates the effect of substitution of microcrystalline cellulose (MCC) with ethylcellulose (EC) on mechanical and release characteristics of theophylline pellets. MATERIALS AND METHODS: The effect of addition of EC was investigated on characteristics of pellets with varying drug content prepared by extrusion-spheronization. Also the effect of type of granulating liquid (water or Surelease) […]
Computational intelligence models to predict porosity of tablets using minimum features.
Abstract The effects of different formulations and manufacturing process conditions on the physical properties of a solid dosage form are of importance to the pharmaceutical industry. It is vital to have in-depth understanding of the material properties and governing parameters of its processes in response to different formulations. Understanding the mentioned aspects will allow tighter control of the process, […]
Artificial neural network modelling of continuous wet granulation using a twin-screw extruder.
Abstract Computational modelling of twin-screw granulation was conducted by using an artificial neural network (ANN) approach. Various ANN configurations were considered with changing hidden layers, nodes and activation functions to determine the optimum model for the prediction of the process. The neural networks were trained using experimental data obtained for granulation of pure microcrystalline cellulose using a […]
Application of halloysite clay nanotubes as a pharmaceutical excipient.
Abstract Halloysite nanotubes, a biocompatible nanomaterial of 50-60nm diameter and ca. 15nm lumen, can be used for loading, storage and sustained release of drugs either in its pristine form or with additional polymer complexation for extended release time. This study reports the development composite tablets based on 50wt.% of the drug loaded halloysite mixed with […]
Comparative binder efficiency modeling of dry granulation binders using roller compaction.
Abstract Roller compaction parameters’ impact on granules and tableting properties of coprocessed Avicel® DG [ADG], a physical mixture of the two components at the same composition present in ADG [PADCP], and microcrystalline cellulose and Kollidon® VA-64 Fine physical mixture [KVA64] was quantified by analysis of variance (ANOVA) and multivariate methods. Roller force, roller gap, and roller speed levels were […]
Effects of excipients and curing process on the abuse deterrent properties of directly compressed tablets.
Abstract The objective of the present investigation was to understand the effects of excipients and curing process on the abuse deterrent properties (ADP) of Polyox™ based directly compressible abuse deterrent tablet formulations (ADFs). The excipients investigated were lactose (monohydrate or anhydrous), microcrystalline cellulose and hydroxypropyl methylcellulose. The ADPs studied were tablet crush resistance or hardness, particle size […]
Microcrystalline-cellulose and polypropylene based composite: A simple, selective and effective material for microwavable packaging.
Abstract Cellulose based composite was successfully designed as active packaging with additional feature of microwavable properties. Small amount of cellulose with 10 μm in diameter was integrated into polypropylene matrix. The use of maleic anhydride was employed as coupling agent. Thermal and mechanical properties of cellulose based composite were superior depending on polypropylene matrix. Crystallization […]
Application of ethyl cellulose, microcrystalline cellulose and octadecanol for wax based floating solid dispersion pellets.
Abstract The present study aimed to develop and optimize the wax based floating sustained-release dispersion pellets for a weakly acidic hydrophilic drug protocatechuic acid to achieve prolonged gastric residence time and improved bioavailability. This low-density drug delivery system consisted of octadecanol/microcrystalline cellulose mixture matrix pellet cores prepared by extrusion-spheronization technique, coated with drug/ethyl cellulose 100cp solid […]
Hydro-liquefaction of microcrystalline cellulose, xylan and industrial lignin in different supercritical solvents.
Abstract The influences of solvent on hydro-liquefaction of cellulose, xylan, and lignin were investigated using micro-autoclave. The maximum conversion and bio-oil yield obtained from cellulose and xylan liquefaction were achieved in methanol, whereas similar liquefaction characteristics of lignin were observed in methanol and ethanol. The molecular simulation of interactions between solvents and subcomponents indicated that […]
Depolymerization of microcrystalline cellulose to value added chemicals using sulfate ion promoted zirconia catalyst.
Abstract The transformation of lignocellulosic biomass to value added chemicals in a synergetic effect of sulfated zirconia (SZ) catalyst and ionic liquid was found to effectively depolymerize microcrystalline cellulose (MCC) to sugars and dehydrate sugars to 5-hydroxylmethylfurfural (5-HMF) and levulinic acid (LA). SZ was catalyst synthesized by wet impregnation method with predetermined concentration of sulphuric acid and […]