Mendonyl™ Povidone (PVP)

The absolute leader in Tablet binding: Simple, Safe, Strong.

Wet Granulation

As illustrated in countless studies (visit our BLOG for more), PVP is widely accepted as the finest binder available for a comprehensive array of formulations that require wet granulation. Its critical impact to the pharmaceutical formulation of small molecule drugs is well-known.

Flexibility

Prevent failure by taking advantage of PVP’s ability to adapt to active compounds in tablets and many other dosage forms, while maintaining stability and quality through all the rigorous production processes, including Spray-drying and roller compaction. With a wide usage range (as low as 1%), achieving solid powders that are easily compressed into tablets and don’t break apart, is at the core of this adaptive binder.

Tough

Recognized, peer-reviewed backed science, means the production of tablets that are easily compressed, and rapidly dissolve in the stomach.

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WHAT IS POVIDONE?

Commonly Povidone (polyvinylpyrrolidone), or simply PVP, is a polymer produced from the monomer, N-vinylpirrolidone, when single molecular units unite to form long polymer chains – a process referred to as “polymerization.” The resulting polymer is an extremely versatile substance, which is used in a great variety of industries, particularly in the pharmaceutical industry, as a binder, film-former, and solubilizing agent. LEARN MORE AT OUR BLOG.

USES IN PHARMACEUTICAL DRUGS:

DIRECT COMPRESSION

WET GRANULATION

BIOAVAILABILITY ENHANCEMENT

PELLETS

SOLUBILIZING AGENT

FILM FORMATION

DISPERSING AGENT

Comparative binder efficiency modeling of dry granulation binders using roller compaction.

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Drug Dev Ind Pharm. 2017 Apr;43(4):574-583. doi: 10.1080/03639045.2016.1272118. Epub 2017 Jan 5. Gupte A1, DeHart M1, Stagner WC2, Haware RV2. Author information 1 a…

08Mar

Pharmaceutical development of an amorphous solid dispersion formulation of elacridar hydrochloride for proof-of-concept clinical studies.

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Drug Dev Ind Pharm. 2017 Apr;43(4):584-594. doi: 10.1080/03639045.2016.1274901. Epub 2017 Jan 8. Sawicki E1, Schellens JH2,3, Beijnen JH1,2,3, Nuijen B1. Author information 1 a…

08Mar

A minitablet formulation made from electrospun nanofibers.

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Eur J Pharm Biopharm. 2017 May;114:213-220. doi: 10.1016/j.ejpb.2017.01.022. Epub 2017 Feb 4. Poller B1, Strachan C2, Broadbent R3, Walker GF4. Author information 1 School…

08Mar

Oral bioavailability enhancement of flubendazole by developing nanofibrous solid dosage forms.

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Drug Dev Ind Pharm. 2017 Jul;43(7):1126-1133. doi: 10.1080/03639045.2017.1298121. Epub 2017 Mar 8. Vigh T1, Démuth B1, Balogh A1, Galata DL1, Van Assche I2, Mackie C2, Vialpando M2, Van…

08Mar

[Application of synthetic and semisynthetic polymers (Kollidon K30 and hydroxypropylmethylcellulose) as carriers of ketoprofen in solid oral prolonged-release dosage forms].

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Polim Med. 2016 Jul-Dec;46(2):145-153. doi: 10.17219/pim/69296. [Article in Polish] Linka W1, Kot M1, Kołodziejczyk M1. Author information 1 Zakład Technologii Postaci Leku, Uniwersytet…

08Mar

New gentle-wing high-shear granulator: impact of processing variables on granules and tabletscharacteristics of high-drug loading formulation using design of experiment approach.

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Drug Dev Ind Pharm. 2017 Oct;43(10):1584-1600. doi: 10.1080/03639045.2017.1326930. Epub 2017 May 19. Fayed MH1, Abdel-Rahman SI2, Alanazi FK3, Ahmed MO2, Tawfeek HM2, Al-Shdefat RI1. Author information…

08Mar

Formulation and Dissolution enhancement of Meloxicam tablets using Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer and Povidone in combination.

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Pak J Pharm Sci. 2017 Mar;30(2):407-414. Noor R1, Hasan SMF1, Hassan F1, Rehman A2. Author information 1 Department of Pharmaceutics, Faculty of Pharmacy and…

08Mar

Influence of polyvinylpyrrolidone, microcrystalline cellulose and colloidal silicon dioxide on technological characteristics of a high-dose Petiveria alliacea tablet.

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Drug Dev Ind Pharm. 2017 Dec;43(12):2011-2015. doi: 10.1080/03639045.2017.1359621. Epub 2017 Aug 3. García-Pérez ME1,2, Lemus-Rodríguez Z1, Hung-Arbelo M1, Vistel-Vigo M1. Author information 1 a…

08Mar

Study of controlled-release floating tablets of dipyridamole using the dry-coated method.

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Drug Dev Ind Pharm. 2018 Jan;44(1):116-124. doi: 10.1080/03639045.2017.1386198. Epub 2017 Oct 17. Chen K1, Wen H1, Yang F1, Yu Y1, Gai X1, Wang H1, Li P1, Pan W1, Yang…

08Mar

Design and Evaluation of Bilayer Pump Tablet of Flurbiprofen Solid Dispersion for Zero-Order Controlled Delivery.

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Design and Evaluation of Bilayer Pump Tablet of Flurbiprofen Solid Dispersion for Zero-Order Controlled Delivery. Cheng L1, Li T1, Dong L1, Wang X1, Huo Q1, Wang H1, Jiang…

TECHNICAL INFORMATION – MENDONYL™ POVIDONE (PVP)

MENDONYL™ K25, K30, K90

Almost white free-flowing powder.

They have a slight characteristic odor, and are practically tasteless.


TEST	K25	K30	K90
Identification, A B C D E	Complies	Complies	Complies
Appearance of solution	Clear, ≤B6,BY6 or R6	Clear, ≤B6,BY6 or R6	Clear, ≤B6,BY6 or R6
PH(in 5% solution)	3-5	3-5	4-7
Viscosity, as K-value	22.5-27	27-32.4	81-97
Aldehyde, ppm	≤500	≤500	≤500
Peroxides (as H2O2), ppm	≤400	≤400	≤400
Formic Acid, %	≤0.5	≤0.5	≤0.5
Hydrazine, ppm	≤1	≤1	≤1
Impurity A (VP),ppm	≤10	≤10	≤10
Impurity B (2-pyrrolidone ),%	≤3.0	≤3.0	≤3.0
Heavy metals, ppm	≤10	≤10	≤10
Water, %	≤5.0	≤5.0	≤5.0
Sulphated ash,%	≤0.1	≤0.1	≤0.1
Assay, as Nitrogen content,%	11.5-12.8	11.5-12.8	11.5-12.8

MENDONYL™ K25, K30, K90

MICROBIOLOGICAL STATUS		MAX 100 Aerobic Plate Count CFU/g
		MAX 100 Mold and Yeast CFU/g
		No Escherichia /g
		No Pseudomonas aeruginosa /g
		No Salmonella /10g
		No Staphylococcus aureus /g

Freely soluble in water and many organic compounds.

Pharmaceutical formulations using PVP:

Nifedipine Tablets

Ingredients	mg/tab
Nifedipine	10
Povidone (K-25)	36
Methylene chloride	168
Microcrystalline cellulose 102	116
Cornstarch	125
Crospovidone	23
Magnesium stearate	.36
Nimesulide	100

Cefdinir Tablets

Ingredients	mg/tab
Cefdinir bulk powder	306.8
Microcrystalline cellulose 101	29.2
L-HPC (LH-21, Shin-Etsu Chemical)	29.2
Povidone (K30)	3.7
Colloidal silicon dioxide	0.9
Magnesium stearate	4.4
Saccharin sodium	15
Strawberry flavor	5.6

Metamizol Tablets (500 mg)

Ingredients	mg/tab
Metamizol sodium (dipyrone)	500
Microcrystalline cellulose 101	100
Povidone (K30)	15
Crospovidone	25
Colloidal silicon dioxide	1
Talc	8
Calcium arachinate	1

Chloroquine Tablets (250 mg)

Ingredients	mg/tab
Chloroquine diphosphate	250
Dicalcium phosphate (Ditab)	100
Povidone (K30)	10
Isopropyl alcohol	83
Crospovidone	10
Colloidal silicon dioxide	2
Talc	3

Vitamin B-Complex, Vitamin C, and Vitamin E Tablets

Ingredients	mg/tab
Niacinamide, (white powder), USP	100
Ascorbic acid; use sodium ascorbate (microcrystalline), USP	843.65
Calcium pantothenate, USP	30
Riboflavin, USP	10
Pyridoxine hydrochloride, USP	5.25
Povidone (K-90)	5.5
Anhydrous isopropyl alcohol	68
Thiamine mononitrate (powder), USP	15.75
Vitamin E, USP, d,l-£\-tocopoheryl acid succinate	33.71
Folic acid (powder), USP	0.18
Magnesium stearate	5
Microcrystalline cellulose 102	40
Vitamin B12; use cyanocobalamine powder in gelatin (1000 £gg/g)	4.2

Sulfadimidine Tablets (500 mg)

Ingredients	mg/tab
Sulfadimidine	500
Lactose monohydrate	100
Povidone (K30)	15
Purified water	200
Crospovidone	25
Talc	2.4
Colloidal silicon dioxide	0.3
Calcium arachinate	0.3

Fucidine Tablets (125 mg)

Ingredients	mg/tab
Fucidine	125
Dicalcium phosphate (Di-Tab)	63
Povidone (90F)	2.5
Isopropyl alcohol	30 mL
Crospovidone	6.2
Colloidal silicon dioxide	1.3
Magnesium stearate	3

Metronidazole Tablets

Ingredients	mg/tablet
Metronidazole	400
Lactose monohydrate	150
Cornstarch	5.7
Povidone (K30)	3
Cornstarch	50
Purified water	121.00 mL
Cornstarch	20
Magnesium stearate	1.25

(source: handbook of Pharmaceutical Manufacturing Formulations, Compressed Solid Products. Author: Sarfaraz K. Niazi)

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QUALITY

Packed in the USA, distributed worldwide, our sample packs were produced directly from our commercial product. Buy with confidence.

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