Comparative binder efficiency modeling of dry granulation binders using roller compaction.
Abstract Roller compaction parameters’ impact on granules and tableting properties of coprocessed Avicel® DG [ADG], a physical mixture of the two components at the same composition present in ADG [PADCP], and microcrystalline cellulose and Kollidon® VA-64 Fine physical mixture [KVA64] was quantified by analysis of variance (ANOVA) and multivariate methods. Roller force, roller gap, and roller speed levels were […]
Effects of excipients and curing process on the abuse deterrent properties of directly compressed tablets.
Abstract The objective of the present investigation was to understand the effects of excipients and curing process on the abuse deterrent properties (ADP) of Polyox™ based directly compressible abuse deterrent tablet formulations (ADFs). The excipients investigated were lactose (monohydrate or anhydrous), microcrystalline cellulose and hydroxypropyl methylcellulose. The ADPs studied were tablet crush resistance or hardness, particle size […]
Application of ethyl cellulose, microcrystalline cellulose and octadecanol for wax based floating solid dispersion pellets.
Abstract The present study aimed to develop and optimize the wax based floating sustained-release dispersion pellets for a weakly acidic hydrophilic drug protocatechuic acid to achieve prolonged gastric residence time and improved bioavailability. This low-density drug delivery system consisted of octadecanol/microcrystalline cellulose mixture matrix pellet cores prepared by extrusion-spheronization technique, coated with drug/ethyl cellulose 100cp solid […]
Processing and characterization of polyols plasticized-starch reinforced with microcrystalline cellulose.
Abstract Biocomposites suitable for short-life applications such as food packaging were prepared by melt processing and investigated. Biocomposites studied are wheat starch plasticized with two different molecular weight polyols (glycerol and sorbitol) and reinforced with various amounts of microcrystalline cellulose. The effect of the plasticizer type and the filler amount on the processing properties, the crystallization […]
Hydro-liquefaction of microcrystalline cellulose, xylan and industrial lignin in different supercritical solvents.
Abstract The influences of solvent on hydro-liquefaction of cellulose, xylan, and lignin were investigated using micro-autoclave. The maximum conversion and bio-oil yield obtained from cellulose and xylan liquefaction were achieved in methanol, whereas similar liquefaction characteristics of lignin were observed in methanol and ethanol. The molecular simulation of interactions between solvents and subcomponents indicated that […]
Depolymerization of microcrystalline cellulose to value added chemicals using sulfate ion promoted zirconia catalyst.
Abstract The transformation of lignocellulosic biomass to value added chemicals in a synergetic effect of sulfated zirconia (SZ) catalyst and ionic liquid was found to effectively depolymerize microcrystalline cellulose (MCC) to sugars and dehydrate sugars to 5-hydroxylmethylfurfural (5-HMF) and levulinic acid (LA). SZ was catalyst synthesized by wet impregnation method with predetermined concentration of sulphuric acid and […]
Impact of degree of oxidation on the physicochemical properties of microcrystalline cellulose.
Abstract Microcrystalline cellulose, a major component of cell wall of plants, is one of the most abundant natural materials, but the poor solubility of cellulose limits its applications. Cellulose is a linear glucan with exclusive β 1→4 linkage. Oxidation carried out with TEMPO-NaBr-NaClO system can selectively oxidize the C6 of glucose residues in cellulose. This […]
Solubility of starch and microcrystalline cellulose in 1-ethyl-3-methylimidazolium acetate ionic liquid and solution rheological properties.
Abstract This study compared the solubility of starch (G50) and microcrystalline cellulose (MCC) in an ionic liquid (IL), 1-ethyl-3-methylimidazolium acetate ([Emim][OAc]), at different temperatures. From SAXS and WAXS analysis, polysaccharides could be totally dissolved in [Emim][OAc]. Fourier-transform infrared (FTIR) spectra showed a similar dissolution mechanism for starch and MCC, which was related to the formation of hydrogen […]
Crospovidone and Microcrystalline Cellulose: A Novel Description of Pharmaceutical Fillers in the Gastrointestinal Tract.
Abstract Crospovidone and microcrystalline cellulose (MCC) are pharmaceutical fillers well known in the pulmonary pathology literature. Fillers are inactive substances incorporated into medications to facilitate drug delivery. By examining 545 consecutive gastrointestinal surgical specimens from 302 patients between September 11, 2015 and October 23, 2015, we identified the fillers in 29 specimens from 26 patients. The control […]
Synergistic effect of chloro and sulphonic acid groups on the hydrolysis of microcrystalline cellulose under benign conditions.
Abstract The hydrolysis of cellulose catalysed by ionic liquid (IL) immobilized on chloromethyl vinyl benzene (CMVB) with different IL/CMVB ratio was carried out in water as a solvent. The influence of process variables like IL/CMVB ratio in catalyst, temperature and time were investigated in a batch reactor. It was found that 40% IL/CMVB catalyst afforded […]