Comparative binder efficiency modeling of dry granulation binders using roller compaction.
0 CommentsDrug Dev Ind Pharm. 2017 Apr;43(4):574-583. doi: 10.1080/03639045.2016.1272118. Epub 2017 Jan 5. Gupte A1, DeHart M1, Stagner WC2, Haware RV2. Author information 1 a…
Read MoreCrospovidone and Microcrystalline Cellulose: A Novel Description of Pharmaceutical Fillers in the Gastrointestinal Tract.
0 CommentsAm J Surg Pathol. 2017 Apr;41(4):564-569. doi: 10.1097/PAS.0000000000000790. Shaddy SM1, Arnold MA, Shilo K, Frankel WL, Harzman AE, Stanich PP, Singhi AD, Yearsley MM, Arnold CA. Author information 1…
Read MoreEvaluation of disintegrants functionality for orodispersible mini tablets.
0 CommentsDrug Dev Ind Pharm. 2017 Nov;43(11):1770-1779. doi: 10.1080/03639045.2017.1339081. Epub 2017 Jun 21. Soulairol I1,2, Chaheen M1,3, Tarlier N1, Aubert A1, Bataille B1, Sharkawi T1. Author information…
Read MoreEffect of experimental design on the prediction performance of calibration models based on near-infrared spectroscopy for pharmaceutical applications.
0 CommentsAbstract Near-infrared spectroscopy (NIRS) is a valuable tool in the pharmaceutical industry, presenting opportunities for online analyses to achieve real-time…
Read MoreFast Disintegrating Combination Tablet of Taste Masked Levocetrizine Dihydrochloride and Montelukast Sodium: Formulation Design, Development, and Characterization.
0 CommentsAbstract The aim of this study was to prepare fast disintegrating combination tablet of taste masked Levocetrizine dihydrochloride and Montelukast…
Read MoreFunctionality of disintegrants and their mixtures in enabling fast disintegration of tablets by a quality by design approach.
0 CommentsAbstract Investigation of the effect of disintegrants on the disintegration time and hardness of rapidly disintegrating tablets (RDTs) was carried…
Read More[Influence of polymer type on the physical properties and the release study of papaverine hydrochloride from tablets].
0 CommentsAbstract BACKGROUND: Polymers are widely used in drug manufacturing. Researchers studied their impact on the bioavailability of active substances…
Read MoreModulation of microenvironmental pH and utilization of alkalizers in crystalline solid dispersion for enhanced solubility and stability of clarithromicin.
0 CommentsAbstract Clarithromycin (CAM) is known to be poorly water-soluble and acid-labile drug. Various alkalizers such as MgO, Na2CO3, Na2HPO4 and…
Read MoreOptimization of Time Controlled 6-mercaptopurine Delivery for Site- Specific Targeting to Colon Diseases.
0 CommentsAbstract BACKGROUND: 6-MP has short elimination time (<2 h) and low bioavailability (~ 50%). Present study was aimed to develop…
Read MoreThe Disintegration Process in Microcrystalline Cellulose Based Tablets, Part 1: Influence of Temperature, Porosity and Superdisintegrants.
0 CommentsAbstract Disintegration performance was measured by analysing both water ingress and tablet swelling of pure microcrystalline cellulose (MCC) and in…
Read MoreTECHNICAL INFORMATION – MCC 102
Appearance | Non fibrous powder | |
Color | White | |
Odor | Odorless | |
Chemical Classification | Organic, carbohydrate |
Identification A | Positive | |
Identification B (Degree of PM) | NMT 350 | |
pH (5g/40ml of water) | 5.0 to 7.0 | |
Loss on drying (as shipped) | NMT 7.0% | |
Residue on ignition (Sulphated Ash) | NMT 0.05% | |
Conductivity (Microsiemens) | NMT 75 | |
Ether-soluble substances | NMT 0.05% | |
Bulk density (g/cm3) | See Table of Comparative Characteristics | |
Heavy metals (Pb) | NMT 10 ppm | |
Water-soluble substances | NMT 0.24% |
Dilute Alkali | Partially soluble | |
Dilute Acid and Organic Solvents | Insoluble | |
Water | Insoluble, Dispersible |
Total Aerobic Microbial Count | NMT 1000 cfu/g | |
Total Combined Molds and Yeasts Count | NMT 100 cfu/g | |
Staphylococcus aureus | Absent/10 g | |
Salmonella sp | Absent/10 g | |
Pseudomonas aeruginosa | Absent/10 g | |
Escherichia coli | Absent/10 g |
Average Particle Size (microns) | 100 |
Retained on 60 mesh (%) | NMT 8 |
Retained on 100 mesh (%) | |
Retained on 100 mesh (%) | NMT 45 |
Loss on Drying (%) | NMT 7 |
Tapped Density (g/cm3) | 0.45 – 0.52 |
Bulk Density (g/cm3) | 0.28 – 0.33 |
Pharmaceutical formulations using MCC 102:
Ingredients | mg/tablet | ||
Prednisolone | 10.5 | ||
Microcrystalline cellulose 102 | 49.5 | ||
Cornstarch | 162 | ||
Lactose monohydrate | 105 | ||
Cornstarch | 10 | ||
Colloidal silicon dioxide | 1 | ||
Magnesium stearate | 1.5 |
Ingredients | mg/tablet | ||
Ranitidine | 85 | ||
Microcrystalline cellulose 102 | 95 | ||
Croscarmellose sodium | 7 | ||
Microcrystalline cellulose 102 | 6.6 | ||
Magnesium stearate | 1.4 |
Ingredients | mg/tablet | ||
Ezetimibe | 10 | ||
Lactose monohydrate | 62.7 | ||
Microcrystalline cellulose 102 | 20 | ||
Povidone (K30) | 7 | ||
Sodium lauryl sulfate | 1 | ||
Croscarmellose sodium | 2.5 | ||
Magnesium stearate | 0.8 | ||
Magnesium stearate | 1.5 |
Ingredients | mg/tablet | ||
Cisapride | 5.2 | ||
Lactose monohydrate | 80.9 | ||
Sodium starch glycolate | 5.5 | ||
Povidone | 45 | ||
Polysorbate 80 | 0.15 | ||
Microcrystalline cellulose 102 | 19.4 | ||
Magnesium stearate | 0.6 |
Ingredients | mg/tablet | ||
Terbinafine (used as terbinafine hydrochloride) | 250 | ||
Hypromellose | 10 | ||
Microcrystalline cellulose 102 | 105 | ||
Croscarmellose sodium | 2.5 | ||
Magnesium stearate | 1.5 |
(source: handbook of Pharmaceutical Manufacturing Formulations, Compressed Solid Products. Author: Sarfaraz K. Niazi)