[title type=”extra-large” color=”#000000″]Microcrystalline Cellulose PH 101[/title]
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[title type=”subtitle-h3″ color=”#999″ animation=”top-to-bottom”]The most effective and widely used binder in Wet Granulations: Powerful, Pure, and Precise[/title]
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[icon_feature icon=”hb-moon-eye-2″ icon_position=”center” border=”yes” title=”Wet Granulation”]As illustrated in countless studies (visit our BLOG for more), MCC 101 is the first-choice binder in a comprehensive array of formulations that require wet granulation. An extraordinary binder, easy to use. [/icon_feature]
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[icon_feature icon=”hb-moon-brain” icon_position=”center” border=”yes” title=”Flexibility”]Realize success with MCC 101’s ability to adapt to active compounds in tablets and powders. With a usage range of 5% to 90%, achieving solid powders that are easily compressed into tablets and don’t break apart, is at the core of this adaptive binder and filler.[/icon_feature]
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[icon_feature icon=”hb-moon-palette” icon_position=”center” border=”yes” title=”Tough”]Old-fashioned, trustworthy toughness means, tablets that won’t break apart, resistant to coatings, and undergoes plastic deformation for ultimate compactability with minimum compression forces.
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| Appearance | Non fibrous powder | |
| Color | White | |
| Odor | Odorless | |
| Chemical Classification | Organic, carbohydrate | |
| Identification A | Positive | |
| Identification B (Degree of PM) | NMT 350 | |
| pH (5g/40ml of water) | 5.0 to 7.0 | |
| Loss on drying (as shipped) | NMT 7.0% | |
| Residue on ignition (Sulphated Ash) | NMT 0.05% | |
| Conductivity (Microsiemens) | NMT 75 | |
| Ether-soluble substances | NMT 0.05% | |
| Bulk density (g/cm3) | See Table of Comparative Characteristics | |
| Heavy metals (Pb) | NMT 10 ppm | |
| Water-soluble substances | NMT 0.24% | |
| Dilute Alkali | Partially soluble | |
| Dilute Acid and Organic Solvents | Insoluble | |
| Water | Insoluble, Dispersible | |
| Total Aerobic Microbial Count | NMT 1000 cfu/g | |
| Total Combined Molds and Yeasts Count | NMT 100 cfu/g | |
| Staphylococcus aureus | Absent/10 g | |
| Salmonella sp | Absent/10 g | |
| Pseudomonas aeruginosa | Absent/10 g | |
| Escherichia coli | Absent/10 g | |
| Average Particle Size (microns) | 50 |
| Retained on 60 mesh (%) | NMT 1 |
| Retained on 100 mesh (%) | – |
| Retained on 100 mesh (%) | NMT 30 |
| Loss on Drying (%) | NMT 7 |
Amoxacillin Tablets
| Ingredients | mg/tablet | ||
| Microcrystalline cellulose | 450 | ||
| Amoxicillin | 287 | ||
| Microcrystalline cellulose 101 | 28.5 | ||
| Crospovidone | 97.5 | ||
| Alcohol 190 proof, approximately | 70.00 mL | ||
| Magnesium stearate | 3.5 | ||
Lorazepam Tablets
| Ingredients | mg/tablet | ||
| Lorazepam | 0.5 | ||
| Lactose monohydrate | 50 | ||
| Cornstarch | 20 | ||
| Hypromellose | 2 | ||
| Microcrystalline cellulose 101 | 25 | ||
| Magnesium stearate | 1 | ||
Irbesartan Tablets
| Ingredients | mg/tablet | ||
| Irbesartana | 75 | ||
| Lactose monohydrate | 15.38 | ||
| Microcrystalline cellulose 101 | 22.5 | ||
| Cornstarch | 22.4 | ||
| Croscarmellose sodium | 7.5 | ||
| Poloxamer 188 (Pluronic F 68) | 4.5 | ||
| Silicon dioxide colloidal | 1.12 | ||
| Magnesium stearate | 1.5 | ||
Acyclovir Tablets
| Ingredient | mg/tablet | ||
| Acyclovir | 800 | ||
| Lactose monohydrate | 240 | ||
| Microcrystalline cellulose 101 | 100 | ||
| Crospovidone | 2.5 | ||
| Cornstarch | 5 | ||
| Magnesium stearate | 8 | ||
Vitamin C Chewable Tablet Formula
| Ingredient | mg/tablet | ||
| Ascorbic acid: 222.20 mg ascorbic acid and 312.50 mg sodium ascorbate microcrystalline | 500 | ||
| Sorbitol (granular) | 850 | ||
| Lactose monohydrate | 100 | ||
| FD&C Yellow Dye No. 5 lake | 3.3 | ||
| Microcrystalline cellulose 101 | 82.9 | ||
| Silica gel | 11.6 | ||
| Flavor | 8.29 | ||
| Flavor | 0.5 | ||
| Sodium cyclamate | 8.29 | ||
| Magnesium stearate | 33.2 | ||
(source: handbook of Pharmaceutical Manufacturing Formulations, Compressed Solid Products. Author: Sarfaraz K. Niazi)
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